1,1-Diaryl-1H-tetrazole amines

Details 1,1-Diaryl-1H-tetrazole amines 1,1-Diaryl-1H-tetrazole amines

1975-07-28

1977-04-12

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029354, 26029369, 260296R, 260308D, 260301G, 26029367, 424272, 424267, 4242484, 424263, C07D40106, C07D40308

Patent

active

040174913

ABSTRACT:
The present invention relates to compounds of the following formula ##STR1## wherein Y is straight or branched chain alkylene containing 1-4 carbon atoms; X is hydrogen, halo such as fluoro, chloro, bromo or iodo, or lower alkyl containing 1-7 carbon atoms; Ar is phenyl, pyridyl, mono-substituted phenyl, wherein the substituent is halo such as fluoro, chloro, or bromo, or lower alkyl having 1-7 carbon atoms; and R.sub.2 and R.sub.3 are lower alkyl having 1-7 carbon atoms, or R.sub.2 and R.sub.3 together with N is an azamonocyclic ring selected from the group comprising 1-pyrrolidinyl, piperidino, 4-phenyl-4-hydroxypiperidino, 4-phenyl-4-hydroxymethylene, 4-phenyl-4-carboxypiperidino, 4-phenyl-4-carbloweralkoxypiperidino, or 4-phenyl-4-acetoxypiperidino substituted piperidino and morpholino, or an azabicycloalkanyl containing 6 to 9 carbon atoms and having at least 5 atoms in each ring of the azabicycloalkane. These compounds are useful intermediates for preparing potent antidiarrheal compounds.

REFERENCES:
patent: 2604473 (1952-07-01), Sperber et al.
patent: 2656358 (1953-10-01), Sperber et al.
patent: 3318869 (1967-05-01), Cusic et al.
Adelstein, "J. Med. Chem.," vol. 16, No. 4, pp. 309-312, Apr. 1973.

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