1,1-bis(p-fluorophenyl)urea

Details 1,1-bis(p-fluorophenyl)urea 1,1-bis(p-fluorophenyl)urea

1985-12-17

1987-10-06

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

546 85, 546 86, 546 87, 564310, C07C12719

Patent

active

046984445

ABSTRACT:
1,1-Di(p-fluorophenyl)urea, 2-carbobenzoxy-8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4, 3-b]indole, an efficient process for converting the former to the latter, further comprising conversion of the latter to 8-fluoro-5-(p-fluorophenyl)-2-[4-(p-fluorophenyl)-4-hydroxybutyl)]-2,3,4,5 -tetrahydro-1H-pyrido[4,3-b]indole (flutroline) or to 8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (an alternative flutroline intermediate).

REFERENCES:
patent: 4001263 (1977-01-01), Plattner et al.
patent: 4014890 (1977-03-01), Welch
patent: 4224329 (1980-09-01), Welch
patent: 4267331 (1981-05-01), Welch
patent: 4568748 (1986-02-01), Massett
Robinson, Chem. Abstracts, vol. 55, (21), pp. 22,194a-b, Oct. 16, 1961.
Romanova et al., Chem. Abstracts, vol. 72, (7), Abst. No. 31, 403z, Feb. 16, 1970.
Weigert et al., The Journal of Organic Chemistry, vol. 41, (25), pp. 4006-4012 (Dec. 10, 1976).
Harbert et al., J. Med. Chem. 23, pp. 635-643 (1980).
Murakami et al., Heterocycles 12, pp. 1571-1574 (1979).
Rylander, "Catalytic Hydrogenation Over Platinum Metals", Academic Press, 1967, pp. 291-303.

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