1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivati

Details 1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivati 1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivati

1987-03-13

1989-09-26

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 514399, 514397, 514383, 514255, 514326, 514274, 514367, 546276, 546278, 546210, 548341, 548335, 548262, 548336, 548202, 548203, 548247, 548179, 544370, 544366, 544318, 544315, 544333, A61K 3144, C07D40112

Patent

active

048700886

ABSTRACT:
Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R.sup.1 where X=oxygen or sulfur and R.sup.1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals ##STR2## where R.sup.2 equals (cyclo)alkyl, acetyl or aryl; or Y equals --NR.sup.3 R.sup.4 where R.sup.3 /R.sup.4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides.
They are obtained by reaction of II ##STR3## with (CH.sub.3).sub.2 ##STR4## and further reaction of the compound IV ##STR5## obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent).
The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.

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