1,1- and 1,2-disubstituted cyclopropane compounds

Details 1,1- and 1,2-disubstituted cyclopropane compounds 1,1- and 1,2-disubstituted cyclopropane compounds

2005-09-13

2005-09-13

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S300000

Reexamination Certificate

active

06943184

ABSTRACT:
A compound selected from those of formula (I):wherein:p represents an integer of from 0 to 6 inclusive,n represents an integer of from 0 to 6 inclusive,R1, and R2represent a group selected from hydrogen, alkyl, aryl and arylalkyl, or R1+R2form together with nitrogen carrying them saturated, monocyclic, or bicyclic system,X represents a group selected from oxygen, sulphur, a group —CH═CH—, methylene, a group of formula —HC═N—O— and a group of formula —O—CH2—CH═CH—, in which groups oxygen is linked to Y of the compounds of formula (I),Y represents a group selected from aryl, heteroaryl, arylalkyl, heteroarylalkyl, —C(O)-A, and —C(S)-A,A represents a group selected from alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, and NR3R4wherein R3, and R4represent a group selected from hydrogen, alkyl, aryl, and arylalkyl, or R3+R4form together with nitrogen carrying them monocyclic, or bicyclic (C3-C10) system,its isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as specific nicotinic ligand of α4β2receptors.

REFERENCES:
Neuropsychopharmacology, 22, 461-565 (2000).
Cur. Med. Chemistry, 8, 651-674 (2001).
Jpn. J. Pharmacol., 88, 133-138 (2002).
J. Pharm. Exp. Ther., 292, 461-467 (2000).
Psychopharmacology, 138, 217-230 (1998).
Psychopharmacology, 143, 158-165 (1999).
Dementia, 7, 47-52 (1996).
Am. J. Psychiatry, 160, 1856-1861 (1993).
Biol. Psychiatry, 32, 607-616 (1992).
Biol. Psychiatry. 44, 98-106 (1998).
Psychopharmacology, 123, 55-63 (1996).
Neuroreport, 9, 57-60 (1998).
Drug Dev. Res., 38, 290-298 (1996).
Brain Res. Bull., 57, 133-150 (2002).
J. Pharm. Exp. Ther., 295, 321-327 (2000).

Affiliated with

Also associated with

Rating

1,1- and 1,2-disubstituted cyclopropane compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,1- and 1,2-disubstituted cyclopropane compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,1- and 1,2-disubstituted cyclopropane compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3385848