1,1-Alkanediol dicarboxylate linked antibacterial agents

Details 1,1-Alkanediol dicarboxylate linked antibacterial agents 1,1-Alkanediol dicarboxylate linked antibacterial agents

1982-09-30

1984-07-03

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

2602391, 2602452R, 2602453, 424250, 424263, 424270, 424271, 424272, A61K 31655, A61K 3143, C07D49932, C07D26300

Patent

active

044579241

ABSTRACT:
Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula ##STR1## where A is the residue of certain dicarboxyic acids, R.sup.3 is H or (C.sub.1 -C.sub.3), n is zero or 1 such that when n is zero R is P or B and R.sup.1 is the residue of certain esters, H or a salt thereof; and when n is 1, one of R and R.sup.1 is P and the other is B, and P is ##STR2## where R.sup.2 is H or certain acyl groups, and B is the residue of a beta-lactamase inhibiting carboxylic acid; a method for their use, pharmaceutical compositions thereof and intermediates useful in their production.

REFERENCES:
patent: 2985648 (1961-05-01), Doyle et al.
patent: 3192198 (1965-06-01), Naylor et al.
patent: 3520876 (1970-07-01), Alburn et al.
patent: 4053360 (1977-10-01), Bouzard
patent: 4234579 (1980-11-01), Barth
patent: 4244951 (1981-01-01), Bigham

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