0-(Substituted-aminoalkyl)-5-nitroimidazole-(2)-aldoximes

Details 0-(Substituted-aminoalkyl)-5-nitroimidazole-(2)-aldoximes 0-(Substituted-aminoalkyl)-5-nitroimidazole-(2)-aldoximes

1974-03-05

1976-04-20

Curtis, Allen B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260309, 424246, 424248, 424263, 424267, 424274, C07D40112, C07D40312, C07D41312, C07D23332

Patent

active

039519635

ABSTRACT:
Novel 0-(dialkylaminoalkyl)-1-alkyl-5-nitroimidazole-(2)-aldoximes are described as well as their manufacture and use for treating protozoal diseases. The novel compounds correspond to the general formula ##SPC1##
In which R.sup.1 stand for a hydrogen atom, a methyl, ethyl or hydroxyethyl group, Z stands for a linear or branched alkylene chain of 2 to 3 carbon atoms, and R.sup.2 and R.sup.3 each stands for an identical or different lower alkyl radical having from 1 to 4 carbon atoms or the group --NR.sup.2 R.sup.3 can be part of a saturated heterocyclic ring which may contain further substituents preferably a methyl group or/and hetero atoms, such as, especially the pyrrolidine, piperidine, morpholine, thiamorpholine, tetrahydro-1,4-thiazine-1,1-dioxide and piperazine ring, and HX can be a non-toxic, physiologically acceptable acid.

REFERENCES:
patent: 3060177 (1962-10-01), Druey et al.
patent: 3299090 (1967-01-01), Hoff et al.
patent: 3634447 (1972-01-01), Gastrock
patent: 3646016 (1972-02-01), Henry et al.
patent: 3660385 (1972-05-01), Albrecht et al.
patent: 3790593 (1974-02-01), Carlson et al.

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