0-hydroxyethyl and acyloxyethyl derivatives of [ser].sup.8 cyclo

Details 0-hydroxyethyl and acyloxyethyl derivatives of [ser].sup.8 cyclo 0-hydroxyethyl and acyloxyethyl derivatives of [ser].sup.8 cyclo

1992-08-27

1994-02-08

Chan, Y. Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530321, 530317, 514863, 514885, 514886, 514880, 514826, A61K 3702, C07K 764

Patent

active

052848264

ABSTRACT:
Hydroxy-substituted [(D)Ser].sup.8 -Ciclosporin derivatives, particularly [O-(2-hydroxyethyl)(D)Ser].sup.8 -Ciclosporin, have advantageous pharmacological properties and are useful as immunosuppressants, for example in the treatment of transplant rejection and autoimmune diseases.

REFERENCES:
patent: 4384996 (1983-05-01), Bollinger et al.
Rudinger, Peptide Hormones, Parsons, J Park Press, Baltimore, pp. 1-7 (1976).
Twentyman et al., Br. J. Cancer vol. 56, pp. 55-57 (1987).

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