0-2-Isocephem-4-carboxylic acid derivatives as antibacterial age

Details 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial age 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial age

1978-07-27

1979-10-16

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D26534

Patent

active

041714385

ABSTRACT:
There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein X is acylamino and Z represents optionally substituted C.sub.1 -C.sub.6 alkyl, aryl or aralkyl. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

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