0-2-Isocephem-4-carboxylic acid derivatives as antibacterial age

Details 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial age 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial age

1976-08-19

1978-01-03

Myers, Jane S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D26534

Patent

active

040668320

ABSTRACT:
There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1##

REFERENCES:
patent: 3835130 (1974-09-01), Woodward
Brunwin et al., J. Chem. Soc. Chem. Comm., 865-867 (1971).
Brunwin et al., J. Chem. Soc. Chem. Comm., 589-590 (1972).
Brunwin et al., J. Chem. Soc. (c), 3756-3762 (1971).
Wolfe et al., Can. J. Chem., 50, 2894-2905 (1972).
Kukolja, J.A.C.S., 93, 6267-6270 (1971).
Kukolja, J.A.C.S., 94, 7590-7593 (1972).
Lowe, et al., J. Chem. Soc. Perkins I, 1321-1328 (1973).
Luttringer et al., Tetrahedron Letters, 4163-4166 (1973).
Sheehan et al., J. Heterocycl. Chem., 5, 779-783 (1968).
Mukerjee et al., Synthesis, 327-346 (1973).

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