Processes for fluorinating aromatic ring compounds

Details Processes for fluorinating aromatic ring compounds Processes for fluorinating aromatic ring compounds

1999-07-27

2000-12-26

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

570144, 560103, 562493, 558411, 564183, 564442, 568656, 568716, 568433, 546345, C07C 2513, C07C 6976, C07C 6304, C07C25500, C07C23300

Patent

active

061662739

ABSTRACT:
A process is provided for increasing the fluorine content of benzene or pyridine rings which are optionally substituted with from 1 to 3 inert substituents. The process involves (a) contacting the ring with a metal fluoride composition comprising cupric fluoride (CuF.sub.2) at a temperature above 250.degree. C. sufficient to transfer F from cupric fluoride to the optionally substituted ring, thereby chemically reducing the metal fluoride composition; (b) oxidizing the reduced metal fluoride composition from (a) in the presence of HF to regenerate a metal fluoride composition comprising cupric fluoride; and (c) employing regenerated metal fluoride composition of (b) in (a).

REFERENCES:
patent: 2892000 (1959-06-01), Skiles
patent: 3398203 (1968-08-01), Olson
patent: 4394527 (1983-07-01), Fischer et al.
patent: 4978649 (1990-12-01), Surovikin et al.
patent: 5756834 (1998-05-01), Pasenok et al.
R.G. Plevey et al., Fluorination with Complex Metal Fluorides Part. II, Journal of Fluorine Chemistry, 3, 259-266, 1973.

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