Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...
Patent
1993-05-26
2000-12-26
Lipman, Bernard
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Polymers from only ethylenic monomers or processes of...
526320, 606 77, 623 11, C08F 2028, A61F 202
Patent
active
061661597
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to novel plastics-based high-strength materials and molded articles manufactured therefrom, which are degradable and resorbable in the human and animal organisms.
2. Discussion of Related Art
In the techniques of clinical surgery, substituting resorbable organic polymers for metal implants is desirable, because thereby a second surgery for removing the implants is rendered unnecessary. Today, resorbable suture materials and resorbable pins for the fixation of bone fragments are known in practical use. These materials used hitherto have been made of poly(lactic acid), poly(glycolic acid), poly(dioxanone) or of copolymers thereof.
The technical utilization of such materials in the form of resorbable plates, screws, nails and the like has failed to come so far. This is due to the following shortcomings, among others, of the materials known till today: The strength of the polymer is too low so that, for example, upon the use of said materials as bolts the heads crack off. There is a high dependency on the predetermined molar weight of the ultimate strength. Processing said materials is extremely expensive.
DE-A1 32 29 635 describes surgical binder systems for adhesion-bonding endogenous hard tissue optionally to plastics and/or metal. Here provided is a resorbable (meth)acrylate component which is liquid to solid at room temperature and consists of (meth)acrylic acid esters with (meth)acrylate moieties on oligoester chains of hydroxycarboxylic acids, said oligoesters having been formed of lower monohydroxymonocarboxylic acids. Here, organoboron compounds have been compulsorily prescribed as the polymerization initiator, which compounds are distinguished by a particularly high activity with respect to polymerization initiation. Said printed publication reporting results of Applicants' own studies was based on the recognition, that the combination of organoboron compounds as the initiator system with, more particularly, the polyfunctional (meth)acrylic acid esters can be especially appropriate for the necessary curing process to form high-strength joint bonds in the area of surgical adhesives.
In this older protective right there has also been referred to the demand for using resorbable supporting materials in surgical techniques, so that a second surgery as otherwise required would be rendered superfluous. Accordingly, in addition to the use of the reactive two-component system, said printed publication describes the use thereof for the in situ manufacture of resorbable molded articles in adhesion-bonding endogenous hard tissue, optionally together with plastics and/or metal. One indispensable component of the molded article formed thereby and, thus, an ingredient of the molded article to be implanted into the living organism is constituted by the organoboron compounds employed as initiators. To this day, materials of this kind have not gained general acceptance in practical use.
DESCRIPTION OF THE INVENTION
The teaching of the present invention provides a new material for the indicated field of use, which material is distinguished by its extremely high and, moreover, even controllable material strength and utilizes the per se known class of oligohydroxycarboxylic acid poly(meth)acrylates, but does not employ initiator systems based on organoboron compounds.
Accordingly, the present invention relates to high-strength materials which are degradable and resorbable in the human and animal organisms and to molded articles manufactured therefrom, such as implants, based on cured (meth)acrylic acid esters of polyfunctionally hydroxyl-terminated oligomers of lower hydroxycarboxylic acids (hereinbelow designated as polyfunctional (meth)acrylic acid esters). Here the term (meth)acrylic acid esters is understood to include the corresponding esters of both acrylic acid and methacrylic acid, while also mixtures of these two ethylenically unsaturated acid components may be present in the same molecule.
The teaching according to the present inven
REFERENCES:
patent: 4626310 (1986-12-01), Ritter
patent: 4731425 (1988-03-01), Ritter
Encyclopedia of Polymer Science and Engineering (2nd Edition) vol. 11, 187-207.
Progress in Polymer Sciience, vol. 8, Pergamon Press, Oxford--New York, 1982, pp. 61-131.
Grandmaison Real J.
Jaeschke Wayne C.
Lipman Bernard
Merck Patent GmbH
Sarofim N.
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