Histidine kinase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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435 691, 4353201, 4352523, 43525411, 435325, 435455, 435471, 536 231, 536 234, 536 237, C07H 2100, C12N 1531, C12N 1562, C12N 1563

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061659924

ABSTRACT:
The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.

REFERENCES:
Evers, et al., "Regulation of VanB-Type Vancomycin Resistance Gene Expression by the VanS.sub.B -VanR.sub.B Two-Component Regulatory System in Enterococcus Faecalis V583", Journal of Bacteriology, vol. 178, No. 5, pp. 1302-1309, Mar. 1996.
Pearson, W. R. et al: "Improved Tools for Biological Sequence Comparison" Proceedings of the National Academy of Sciences of USA, vol. 85, pp. 2444-2448, 1998.
Perez, A.: "Streptococcus Pneumoniae fba gene" EMBL Database, Accession No. AJ005697, Apr. 27, 1998.
Swanson, R. V., et al: "Histidine and Aspartate Phosphorylation: Two Component Systems and the Limits of Homology" Trends in Biochemical Sciences, vol. 19, No. 11, pp. 485-490, 1994.
Evers, S., et al: "Regulation of the VanB-Type Vancomycin Resistance Gene Expression by the VansB-VanrB Two-Component Regulatory System in Entrococcus Faecalis V583" Journal of Bacteriology, vol. 178, No. 5, pp. 1302-1309, 1996.

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