Recombinant production of immunoglobulin-like domains in prokary

Details Recombinant production of immunoglobulin-like domains in prokary Recombinant production of immunoglobulin-like domains in prokary

1994-11-17

2000-12-26

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 711, 4352523, 436547, C12P 2106

Patent

active

06165745&

ABSTRACT:
Disclosed are recombinant vectors encoding immunoglobulin-like domains and portions thereof, such as T-cell variable domains, antibody Fc-hinge fragments, subfragments and mutant domains with reduced biological half lives. Methods of producing large quantities of such domains, heterodimers, and fusion proteins following expression and secretion by prokaryotic host cells are also reported. Described are single chain T-cell receptors, which are folded into .beta.-pleated sheet structures similar to those of immunoglobulin variable domains; antibody Fc and Fc-hinge domains, which have the same in vivo stability as intact antibodies; and domains engineered to have reduced half lives.

REFERENCES:
Waldmann, Science, vol. 252, pp. 1657-1662, Jun. 21, 1991.

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