Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-04-16
2000-12-26
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 791, 435 23, 4352523, 43525233, 4353201, 536 232, C12Q 100, C12Q 137, C12N 964, C12N 1570, C12N 1574
Patent
active
061657379
ABSTRACT:
The invention provides methods and compositions relating to DNA Fragmentation Factor (DFF) polypeptides and related nucleic acids. More particularly, the present invention provides the sequence for the active subunit of DFF. The polylpeptides may be produced recombinantly from host cells transformed from the disclosed DFF encoding nucleic acids or purified from human cells. The invention provides isolated DFF hybridization probes and primers capable of specifically hybridization with the disclosed DFF genes, DFF-specific binding agents such as specific antibodies, and methods of making and using the subject compositions.
REFERENCES:
patent: 5912141 (1999-06-01), Brojatsch et al.
Alnemri et al., "Human ICE/CED-3 protease nomenclature," Cell, 87:171, 1996.
Casicola-Rosen et al., "Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death," J. Exp. Med., 183:1957-1964, 1996.
Chinnaiyan et al., "Molecular ordering of the cell death pathway," J. Biol. Chem., 271(9):4573-4576, 1996.
Darmon et al., "Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation," J. Biol. Chem., 271:21709-21712, 1996.
Datta et al., "Activation of the CPP32 protease in apoptosis induced by 1-.beta.-D-arabinofuranosylcytosine and other DNA-damaging agents," Blood, 88(6):1936-1943, 1996.
Datta et al., "Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis," J. Biol. Chem., 272(3):1965-1969, 1997.
Dubrez et al., "Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways," J. EMBO., 15(20):5504-5512, 1996.
Enari et al., "Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis," Nature, 380:723-726, 1996.
Enari et al., "A caspase-activated Dnase that degrades DNA during apoptosis, and its inhibitor ICAD," Nature, 391(1):43-50, 1998.
Erhardt and Cooper, "Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-x.sub.L," J. Biol. Chem., 271(30):17601-17604, 1996.
Faleiro et al., "Multiple species of CP 32 and Mch2 are the major active caspases present in apoptotic cells," J. EMBO, 16:2271-2281, 1997.
Fernandes-Alnemri et al., "CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1.beta.-converting enzyme," J. Biol. Chem., 269(49):30761-30764, 1994.
Goldberg et al., "Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract," Nat. Genet., 13(4):442-449, 1996.
Hartl et al., "Molecular chaperones in protein folding: the art of avoiding sticky situations," TIBS, 19:20-25, 1994.
Hasegawa et al., "Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis," Cancer Res., 56:1713-1718, 1996.
Jackson et al., "Chromatin fractionation procedure that yields nucleosomes containing near-stoichiometric amounts of high mobility group nonhistone chromosomal proteins," Biochemistry, 18:3739-3748, 1979.
Jacobson et al., "Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death," J. Cell Biol., 133(5):1041-1051, 1996.
Kaufman et al., "Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early mark chemotherapy-induced apoptosis," Cancer Res., 53:3976-3985, 1993.
Kerr et al., "Apoptosis: a basic biologial phenomenon with wide-ranging implications in Tissue Kinetics," Br. J. Cancer, 26:239-257, 1972.
Khokhlatchev et al., "Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria," J. Biol. Chem., 272(17):11057-11062, 1997.
Kuida et al., "Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice," Nature, 384:368-372, 1996.
Lazebnik et al., "Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution," Proc. Natl. Acad. Sci. USA, 92:9042-9046, 1995.
Liu et al., "Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c," Cell, 86:147-157, 1996.
Liu et al., "DFF, a heterodimeric protein that functions downstream of Caspase-3 to trigger DNA fragmentation during apoptosis," Cell, 89:175-184, 1997.
Liu et al., "Purification and Characterization of an Interleukin-1.beta.-converting Enzyme Family Protease that Activates Cysteine Protease P32 (CPP32)*," J. Biol. Chem., 271:13371-13376, 1996.
Luo and Sawadogo, "Functional domains of the transcription factor USF2: Atypical nuclear localization signals and context-dependent transcriptional activation domains," Mol. Cell Biol., 16(4):1367-1375, 1996.
Martin et al., The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism, J. EMBO, 15(10):2407-2416, 1996.
Martins et al., "Activation of multiple interleukin-1.beta.-converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis," J. Biol. Chem., 272:7421-7430, 1997.
Na et al., "D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis," J. Biol. Chem., 271(19):11209-11213, 1996.
Nicholson and Thornberry, "Caspases: killer proteases," TIBS, 257:299-306, 1997.
Nicholson et al., "Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis," Nature, 376:37-43, 1995.
Paine et al., "Protein loss during nuclear isolation," J. Cell Biol., 97:1240-1242, 1983.
Peters et al., "Evidence for the location of high mobility group protein T in the internucleosomal linker regions of trout testis chromatin," J. Biol. Chem., 254:3358-3361, 1979.
Radler et al., "Structure of DNA-cationic liposome complexs DNA intercalation in multilamellar membranes in distinct interhelical packing regimes," Science, 275:810-814, 1997.
Roche et al., "The involvement of histone H1.degree. in chromatin structure," Nucleic Acids Res., 13:2843-2853, 1985.
Sakahira et al., "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis," Nature, 391(1):96-99, 1998.
Schlegel et al., "CPP32/Apopain is a key interleukin 1.beta. converting enzyme-like protease involved in Fas-mediated apoptosis," J. Biol. Chem., 271:1841-1844, 1996.
Schroter and Bode, "The binding sites for large and small high-mobility-group (HMG) proteins," Eur. J. Biochem., 127:429-436, 1982.
Shiraishi et al., "Adenovirus-mediated gene transfer using in-situ perfusion of the liver graft," Transplant International, 10(3):202-206, 1997.
Smith and Moss, "Infectious poxvirus vectors have capacity for a least 25000 base pairs of foreign DNA," Gene, 25:21-28, 1983.
Song et al., "DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis," J. EMBO, 15(13):3238-3246, 1996.
Song et al., "DCP-1, a drosophila cell death protease essential for development," Science, 275:536-540, 1997.
Sun et al., "Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation," J. Exp. Med., 179:559-568, 1994.
Takahashi et al., "Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8," Oncogene, 14:2741-2752, 1997.
Tam et. al., "SN.sup.2 deprotection of synthetic peptides with a low concentration of HF in dimethyl sulfide: evidence and application in peptide synthesis," J. Am. Chem. Soc., 105:6442-6455, 1983.
Tewari et al., "Yama/CPP32.beta., a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase," Cell, 81:801-809, 1995.
Vaux, "CED-4--The third horseman of apoptosis," Cell, 90:389-390, 1997.
Walther and Stein, "Cell type specific and inducible promoters for vectors in gene therapy as an approach for cell targeting," J. Mol. Med., 74:379-392, 1996.
Wang et al., "Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP 32 during apoptosis," J. EMBO, 15:1012-1020, 1996.
Wang et al., "Mice lacking ADPRT and poly(ADP-ribosyl
Liu Xuesong
Wang Xiaodong
Achutamurthy Ponnathapu
Moore William W.
The University of Texas System & Board of Regents
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