Antisense modulation of NCK-2 expression

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 911, 435325, 536 245, C07H 2104, C12Q 168, C12N 1585

Patent

active

06165728&

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of nck-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding nck-2. Methods of using these compounds for modulation of nck-2 expression and for treatment of diseases associated with expression of nck-2 are provided.

REFERENCES:
patent: 5352660 (1994-10-01), Pawson
patent: 5780496 (1998-07-01), Tang et al.
patent: 5801154 (1998-09-01), Baracchini et al.
Branch, A good antisense molecule is hard to find, TIBS, vol. 23, pp. 45-50, Feb. 1998.
Agrawal, Antisense oligonucleotides:towards clinical trials, TIBTECH, vol. 14, pp. 376-387, Oct. 1996.
Gewirtz et al., Facilitating oligonucleotides delivery: helping antisense deliver on its promise, PNAS, vol. 93, pp. 3161-3163, Apr. 1996.
Braverman et al., Identification of Grb4/Nckbeta, a src homology 2 and 3 domain- containing adapter protein having similar binding and biological properties to Nck, J. Biol. Chem., 1999, 274:5542-5549.
Chen et al., Identification of Nck family genes, chromosomal localization, expression, and signaling specificity, J. Biol. Chem., 1998, 273:25171-25178.
Pawson, Protein modules and signalling networks, Nature, 1995, 373:573-580.
Tu et al., The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells, Mol. Cell. Biol., 1999, 19:2425-2434.
Tu et al., Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways, Mol. Biol. Cell., 1998, 9:3367-3382.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antisense modulation of NCK-2 expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense modulation of NCK-2 expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense modulation of NCK-2 expression will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-993216

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.