Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-12-30
2000-12-26
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 435455, 536 221, 536 231, 536 2433, C12Q 164, C12N 1563, C07H 2100
Patent
active
061657204
ABSTRACT:
Complexes comprising a nucleic acid molecule and a conjugated peptide nucleic acid (PNA). The PNA may be labeled or conjugated to a protein, peptide, carbohydrate moiety or receptor ligand. These complexes are used to transfect cells to monitoring plasmid biodistribution, promote nuclear localization, induce transcriptional activation, lyse the endosomal compartment and facilitate transfection. These complexes increase the efficiency of expression of a particular gene.
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Bennett C. Frank
Felgner Philip L.
Zelphati Olivier
Gene Therapy Systems
ISIS Pharmaceuticals Inc.
Schwartzman Robert A.
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