Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-12-03
1995-12-19
Criares, T. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142388, 514212, 514329, 514330, 514567, 514615, 514617, 514619, 514535, 514561, 514399, 514866, 514913, 514400, 514632, A61K 31535, A61K 3155, A61K 31445, A61K 31195, A61K 3116, A61K 31165, A61K 3114, A61K 31415, A61K 31155
Patent
active
054768497
ABSTRACT:
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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Cerami Anthony
Ulrich Peter C.
Wagle Dilip R.
Alteon Inc.
Criares T. J.
The Rockefeller University
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