Liquid purification or separation – With means to add treating material – Chromatography
Patent
1998-04-29
2000-04-25
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
656659, 656143, 422 70, B01D 1508
Patent
active
060540478
ABSTRACT:
Disclosed are apparatus for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. The apparatus of this invention also permit a compound library to be rapidly screened to determine if any member of the library has a higher affinity for the target receptor relative to a pre-selected indicator compound.
REFERENCES:
patent: 4842701 (1989-06-01), Smith et al.
patent: 4869093 (1989-09-01), Gilbert
patent: 4970085 (1990-11-01), Persson
patent: 5106756 (1992-04-01), Zaromb
patent: 5481476 (1996-01-01), Windig
patent: 5503805 (1996-04-01), Sugarman
patent: 5561046 (1996-10-01), Baxter
patent: 5646046 (1997-07-01), Fischer
patent: 5792431 (1998-08-01), Moore
patent: 5917185 (1999-06-01), Carson et al.
Bean, K.A., J Chromatogr B Biomed Sci Appl., 1997, 690, 65-75.
Calaf, R.E., et al., Rapid Commun Mass Spectrom, 1997, 11, 75-80.
Cornpropst, J.D., et al., J. Chromatogr B Biomed Sci Appl., 1995, 673, 67-74.
Chu, Y. -H., et al., J. Am. Chem. Soc. 1996, 118, 7827-7835.
Fang, L., et al., In Proceedings of the 45.sup. th ASMS Conference on Mass Spectrometry and Allied Topics, Palm Springs, CA, Jun. 1-5, 1997; p. 401.
Gaskell, S.J., Journal. Mass Spectrometry, 1997, 32, 677-688.
Griffey, R. H., et al., In Proceedings of the 45.sup.th ASMS Conference on Mass Spectrometry and Allied Topics, Palm Springs, CA, Jun. 1-5, 1997: p. 400.
Hage, D.S., et al., Journal of Chromatography B, 1997, 699, 499-525.
Hille, J., Journal of Chromatography, 1990, 502, 265-274.
Hoja, H., et al., J Chromatogr B Biomed Sci Appl., 1997, 692, 329-335.
Hsieh, Y. F., et al., J. Mol. Div. 1996, 2, 189-196.
Hua, Y., et al., Anal. Chem., 1995, 67, 1815-1823.
James, S., et al., Anal. Biochem., 1994, 217, 84-90.
Jemal, M., et al., J Chromatogr B Biomed Sci Appl., 1997, 693, 109-116.
Kasai, Ken-Ichi, et al., J. Chromatogr B Biomed Appl., 1986, 376, 33-47.
Klein, A., et al., Glycobiology, 1997, 7, 421-432.
Lam, K. S., Anti-Cancer Drug Des. 1997, 12, 145-167.
Lin, S., et al., Anal. Chem., 1996, 68, 4087-4093.
Nedved, M. L., et al., Anal. Chem., 1996, 68, 4228-4236.
Nelson, R. W. et al., Anal. Chem., 1995, 67, 1153-1158.
Pais, P., et al., J. Chromatogr A, 1997, 775, 125-136.
Piperopoulos, G., et al., J Chromatogr B Biomed Sci Appl, 1997, 695, 309-316.
Rouhi, A. M., C&EN News, pg. 46-53 (Mar. 16, 1998).
Schriemer, D.C., et al., Anal. Chem., 1996, 68, 3382-3387.
Stinson, S.C., C&EN News, p. 42-45, (Mar. 16, 1998).
Sweetnam, P. M., et al., In Burger's Medicinal Chemistry and Drug Discovery; M.E. Wolfe, Ed., John Wiley & Sons: New York, 1995; pp. 697-731.
van Breeman, R. B., et al., Anal. Chem., 1997, 69, 2159-2164.
Volmer, D.A., et al., Anal. Chem., 1997, 69, 143-155.
Volmer, D.A., Rapid Commun Mass Spectrom, 1998, 10, 1615-1620.
Wieboldt, R., et al., Anal. Chem., 1997, 69, 1683-1691.
Xue, Qifeng, et al., Anal. Chem., 1997, 69, 426-430.
Zell, M., et al., Rapid Commun Mass Spectrom, 1997, 11, 1107-1114.
Zhao, Y. -Z., et al., j. Med. Chem., 1997, 40, 4006-4012.
van Breemen, Richard B., et al., Pulsed Ultrafiltration Mass Spectrometry: A New Method for Screening Combinatorial Libraries., Analytical Chemistry (Jun. 1997), vol. 69, pp. 2159-2164.
Kasai, Ken-Ichi, et al., Frontal Affinity Chromatography: Theory for its Application to Studies on Specific Interactions of Biomolecules, Journal of Chromatography, (1986) vol. 376, pp. 33-47.
Blanar, et al. Interaction Cloning: Identification of a Helix-Loop-Helix Zipper Protein That Interacts with c-Fos. Science, vol. 26. May 15, 1992: 1014-1018.
Ellison, et al. Epitope-tagged Ubiquitin: A New Probe for Analyzing Ubiquitin Function. American Society for Biochemistry and Molecular Biology, 266:31, Nov. 5, 1991: 21150-21157.
Field, et al. Purification of a RAS-Responsive Adenylyl Cyclase Complex from Saccharomyces cervisiae by Use of an Epitope Addition Method. Molecular and Cellular Biology, May 1988, 2159-2165.
Gerard, et al. Contruction and Expression of a Novel Recombinant Anaphylatoxin, C5a-N19, as a Probe for the Human C5a Receptor. Biochemistry 1990, 29, 9274-9281.
Hanke, et al. Contruction of solid matrix-anibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen, Journal of General Virology, 1992, 72, 653-660.
Herman, et al. Affinity Chromatography of DNA Labeled with Chemically Cleavable Biotinylated Nucleotide Analogs. Analytical Biochemistry, vol. 156, 1986, 48-55.
Hopp, et al. A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification. Bio/Technology, vol. 6, Oct. 1988, 1204-1210.
Kim, et al. Isolation of a Terminal Cisterna protein Which May Link theDihydropyridine Receptor to the Junctional Foot Protein in Skeletal Muscle. Biochemistry, 1990, 29, 9281-9289.
Kilmartin, et al. Rat monoclonal Antitubulin Antibodies Derived by Using a New Nonsecreting Rat Cell Line. The Journal of Cell Biology, vol. 93, Jun. 1982, 576-582.
Lim, et al. Distribution and Specific Identification of Papillomavirus Major Capsid Preotein Epitopes by Immunocytochemistry and Epitope Scanning of Synthetic Peptides. Journal of Infectious Diseases 1990, 162, 1263-1269.
Lin, et al. Two-Step Affinity Chomatography, Model Systems and an Example Using Biotin-Avidin Binding and a Fluoridolyzable Linker. J. Org. Chem. 1991, 56: 6850-6856.
Pati. Novel vector for expression of cDNA encoding epilope-tagged proteins in mammalian cells. Gene, 1992, 114, 285-288.
Sassenfeld. Engineering proteins for purification. Tibtech, 1990, 8, 88-93.
Skinner, et al. Use of the Glu-Glu-Phe C-terminal Epitope for Rapid Purification of the Catalytic Doman of Normal and Mutant re GIPase-activating Proteins. The Journal of Biological Chemistry. 266:22, Aug. 5, 1991, 14163-14166.
Stammers, et al. Rapid purification and characterisation of HIV-1 reverse transcriptase and RnaseH engineered to incorporate a C-terminal tripeptide .alpha.-tubulin epitope. Febs Letters, 283:2, Jun. 1991, 298-302.
von Zastrow, et al. Ligand-regulated Internalization and Recycling of Human .beta.2-Adrenergic Receptors between the Plasma Membrane and Endosomes Containing Transferrin Receptors. The Journal of Biological Chemistry, 67:5, Feb. 1992, 3530-3538.
Wadzinski, et al. NH.sub.2 -terminal Modification of the Phosphatase 2A Catalytic Subunit Allows Functional Expression in Mammalian Cells. The Journal of Biological Chemistry, 267:24, Aug. 1992, 16883-16888.
Garr, The Use of Evaporative Light Scatterin in Quality Control of Combinatorial Libraries, MDS Panlabs, Inc. Apr. 28-29, 1997, pp. 1-18.
Hindsgaul Ole
Schriemer David C.
Synsorb Biotech Inc.
Therkorn Ernest G.
LandOfFree
Apparatus for screening compound libraries does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Apparatus for screening compound libraries, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Apparatus for screening compound libraries will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-990806