System and method for modulating the base rate during sleep for

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems

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A61N 1365

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active

054764831

ABSTRACT:
A system and method are provided for modulating the base rate of a transfer function for a rate-responsive cardiac pacemaker. Activity sensor measurements are used to derive activity variance measurements, which in turn are used to modulate the base pacing rate. In one embodiment, a histogram is used to store activity variance measurements collected over a period of about a week. The histogram is used to derive an activity variance threshold, which is compared to current activity variance measurements to determine if the patient is sleeping. If the patient is deemed to be sleeping, the pacing rate is set to a rate that comfortably meets the patient's low metabolic demands during sleep. In alternative embodiments, the activity variance measurements are applied to a base rate slope to modulate the base pacing rate.

REFERENCES:
patent: 5040534 (1991-08-01), Mann et al.
patent: 5074302 (1991-12-01), Poore et al.
patent: 5143065 (1992-09-01), Adkins et al.
Michael T. Lee and Ross Baker, "Circadian Rate Variation in Rate Adaptive Pacing Systems," Page, vol. 13, pp. 1797 1801, Dec. 1990.
Milan Djordjevic, rt al., "Circadian Variations of Heart and Stim-T Interval: Adaptation for Nighttime Pacing," Pace, vol. 12, pp. 1757-1762, Nov. 1989.

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