Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-07-01
1995-06-06
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514703, 554224, 5689095, A61K 3120
Patent
active
054223717
ABSTRACT:
Disclosed are a novel class of anti-androgenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, according to the following formula:
REFERENCES:
patent: 4191759 (1980-03-01), Johnston et al.
patent: 4220775 (1980-09-01), Rasmusson et al.
patent: 4694023 (1987-09-01), Loev et al.
patent: 4759880 (1988-07-01), Nicolaok et al.
patent: 5032514 (1991-07-01), Anderson et al.
Dinadiao, May Clin. Proc. 66:1018-1028 (1991).
Downing, et al., J. Am. Acad. Dermo. 14:221-225 (1986).
Ehrmann and Rosenfield, J. Clin. Endocrinol. Metab. 71:1 (1990).
Evans, Science 240:889 (1989).
Fang and Liao, Mol. Pharmacol. 5:428 (1969).
Frost and Gomez, Adv. Biol. Skin. 12:403 (1972).
Gent and Ho, Biochemistry 17:3023 (1978).
Gent, et al., J. Biophys. 33:211 (1981).
George, et al., Endocrinology 119:959 (1989).
Gershon and Parmegiani, J. Med. Chem. 10:186 (1967).
International Search Report, PCT/US93/04090.
Anderson and Liao, Nature 219:277 (1968).
Baba, et al., J. Neurochem. 42:192 (1984).
Beato, Cell 56:335 (1989).
Begin, Proc. Nutrition Soc. 49:261-267 (1990).
Bingham and Shaw, J. Endocr. 57:111 (1973).
Bjorneboe, et al., Brit. J. Dermatol. 118:77-83 (1988).
Blohm et al., Endocrinology 119:959 (1986).
Blohm, et al., Biochem. Biophy. Res. Commun. 95:273 (1989).
Bradnt, et al., J. Steroid Biochem Mol. Biol. 37:575 (1990).
Bruchovsky and Wilson, J. Biol. Chem. 243:2012 (1968).
Brooks, et al., Proc. Soc. Esp. Biol. Med. 169:67 (1982).
Brooks, et al., Endocrinology 109:830 (1981).
Brooks, et al., The Prostate 3:35 (1982).
Carter and Coffrey, The Prostate 16:39-48 (1990).
Chang and Liao, J. Steroid Biochem. 27:123 (1987).
Cooke and Robaire, J. Biol. Chem. 260:7489 (1985).
Cusan, et al., J. Am. Acad. Dermatol. 23:462-469 (1990).
Dell and Severson, Biochem. J. 258:171 (1989).
Diani et al., J. Clin Endocr. and Metabl. 74:345 (1992).
Gittes, New England J. Med. 324:236 (1991).
Gormley, et al., J. Clin. Endocrinol. Metab. 70:1136 (1990).
Gorski, et al., Ann. Rev. Physiol. 42:17 (1976).
Halgunset, et al., J. Steroid Biochem. 28:731 (1983).
Hall, New Phytol. 71:855 (1972).
Hamilton, Am. J. Anat. 71:451 (1942).
Hammerstein, et al., J. Steroid Biochem. 19:591 (1983).
Hebborn, et al., Arch Dermatol. 124:387-391 (1988).
Herold and Kinsella, Am. J. Clin. Nutr. 43:566 (1986).
Hiipakka, et al., Endocrine Dependent Tumors, ed. Voight & Knabbe 2:43-61 (1991).
Horrobin, et al., J. Am. Acad. Dermatol. 20:1045-53 (1989).
Horszewicz, et al., Cancer Res. 43:1809 (1983).
Huggins and Hodges, Cancer Res. 1:293 (1940).
Ichihara and Tanaka, Biochem. Biophys. Res. Comm. 149:481 (1981).
Imperato-McGinley, Trend Genet. 2:130 (1986).
Imperato-McGinley, et al., J. Clin. Endocr. Metab. 70:77 (1990).
Isaacs, J. Clin. Endocr. Metab. 56:139 (1983).
Jensen, et al., Proc. Nat'l Acad. Sci. (USA) 59:632 (1968).
Kaighn, et al., Invest. Urol. 17:16 (1979).
Karmali, et al., J. Nat'l Cancer Inst. 73:457 (1984).
Kato, J. Steroid Biochem. 34:219 (1989).
Khan, et al., Febs Letter 292:98 (1991).
Kwok, et al., J. Am. Chem. Soc. 109:3684 (1987).
Lands, Ann. Rev. Biochem. 34:313 (1965).
Liang, et al., Endocrinology 112:1460 (1983).
Liang, et al., Endocrinology 115:2311 (1984).
Liang and Heiss, J. Biol. Chem. 256:7998 (1981).
Liang, et al., J. Steroid Chem. 19:385 (1983).
Liang and Liao, Clin. Research 39:720A (1991).
Liao and Fang, Vitamins and Hormones 27:17 (1974).
Liao, et al., Endocrinology 94:1205 (1974).
Liao, et al., J. Biol. Chem. 248:6154 (1973).
Liao, Int. Rev. Cytology 41:87 (1975).
Liao, et al., J. Steroid Biochem. 34:41-51 (1989).
Mock, et al., J. Pediatrics 106:762 (1985).
Moguilewsky and Bouton, J. Steroid Biochem. 31:699 (1988).
Mooradian et al., Endocrine Rev. 8:1 (1987)
Morello, et al., Invest. Derm. 66:319 (1976).
Morse, et al., Brit. J. Dermatol. (1989) 121:75-90.
Munnich, et al., Lancet 2:1080 (1980).
Nalboone, et al., Lipids 25:301 (1990).
Needleman, et al., Ann. Rev. Biochem. 55:69 (1986).
Newman, Proc. Nat'l Acad. Sci. 87:5543-5547 (1990).
O'Malley, Mol. Endocrinol. 4:363 (1990).
Pattison and Buchanan, Biochem, J. 92:100 (1964).
Phillipson, et al., Eng. J. Med. 312:1210 (1985).
Pochi, Ann. Rev. Med. 41:187 (1990).
Rasmusson, et al., J. Med. Chem. 29:2298 (1986).
Rittmaster, et al., J. Androl. 10:259 (1989).
Rittmaster, et al., J. Clin. Endocr. Metab. 65:188-193 (1987).
Rose and Connolly, The Prostate 18:243-254 (1991).
Sansone and Reisner, J. Invest. Dermatol. 56:366 (1971).
Schafer and Kragballe, Lipids 26:557-560 (1991).
Schweikert and Wilson, Clin. Endocrinol. Metab. 38:811 (1974).
Serafini and Lobo, Fert. Steril. 43:74 (1985).
Siiteri and Wilson, J. Clinical Invest. 49:1737 (1970).
Strauss and Yesalis, Ann. Rev. Med. 42:499 (1991).
Strong, et al., Brit. J. Clin. Prac. Nov./Dec.:444-445 (1985).
Synder, Ann. Rev. Med. 35:207 (1984).
Szepesi, et al., J. Nutr. 119:161 (1989).
Tesoriere et al., J. Neurochem. 51:704 (1988).
Tosaki and Hearse, Basic Res. Cardiol. 83:158 (1988).
Vallette, et al., J. Steroid Biochem. 263:3639 (1988).
Vermeulen et al., The Prostate 14:45 (1989).
Voigt, et al., J. Biol. Chem. 248:4248 (1973).
Wenderoth and George, Endocrinology, 113:569 (1983).
Wilson, Am. J. Med. 68:745 (1980).
Wright, Prostaglandins, Leukotrienes and Essential Fatty Acids 38:229 (1989).
Ziboh and Miller, Ann. Rev. Nutr. 10:433 (1990).
Ziboh, Arch Dermatol. 125:241-245 (1989).
Zuniga, et al., J. Nutr. 119:152 (1989).
Begin, et al., NJCI, 5:1053-1061 (1986).
Anderson, et al., Prostaglandins, Leukotrienes and Essential Fatty Acids, 40:137-141 (1990).
Liang, et al., J. Biol. Chem. 260:4890-4895 (1985).
Liang Tehming
Liao Shutsung
Arch Development Corp.
Shah Mukund J.
Sripada P. K.
LandOfFree
Methods and compositions for inhibiting 5.alpha.-reductase activ does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for inhibiting 5.alpha.-reductase activ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for inhibiting 5.alpha.-reductase activ will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-988024