Detection of brain .alpha.1-antichymotrypsin

Details Detection of brain .alpha.1-antichymotrypsin Detection of brain .alpha.1-antichymotrypsin

1992-05-05

1995-06-06

Bidwell, Carol E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 435 794, 435971, 436518, 436536, 436811, 436827, G01N 33543

Patent

active

054222443

ABSTRACT:
The present invention is related generally to methods and compositions for identifying and quantitating particular .alpha.1-antichymotrypsin species in a biological sample. More particularly, the present invention is related to methods and compositions for detecting and measuring a brain .alpha.1-antichymotrypsin species that is produced in brain tissue of individuals having a neuropathological condition and which is detectable in accessible biological samples. The invention provides detection assays, such as sandwich binding assays, for detecting and quantitating brain .alpha.1-antichymotrypsin in a biological sample, such as blood, urine, cerebrospinal fluid, or tissue. These detection assays are useful for detecting and diagnosing neuropathological diseases and for identifying cells of a human central nervous system lineage, and for other medical applications. The invention also provides binding components, such as antibodies that bind to brain .alpha.1-antichymotrypsin, and which have potential therapeutic and diagnostic medical imaging applications.

REFERENCES:
patent: 5008242 (1991-04-01), Lezdey et al.
Slifkin et al. "Lectins and Their Application to Clinical Microbiology", Clin. Microbiol. Rev. 3(3): 197-218 (Jul. 1990).
Matsubara et al, ".alpha.1-Antichymotrypsin as a Possible Biochemical Marker for Alzeheimer-Type Dementia", Ann. Neurol., 28: 561-567 (Oct. 1990).
Travis et al, "Human .alpha.-1-Antichymotrypsin: Purification and Properties", Biochem. 17(26): 5647-5651 (1978).
Sevier et al. "Monoclonal Antibodies in Clinical Immunology", Clin. Chem., 27(11): 1797-1806 (Nov. 1981).
Abraham et al. (1988), Cell 52:487-501.
Abraham and Potter (1989), Ann. Med. 21:77-81.
Baumann et al. (1991), J. Mol. Biol. 218:595-606.
Berninger (1986), J. Med. 16:101-128.
Hachulla et al. (1992), Clinical Science 82:439-446.
Kelsey et al. (1988), J. Med. Genet. 25:361-368.
Koo et al. (1991), Neurobiology of Aging 12:495-501.
Laine et al. (1991), Eur. J. Biochem. 197:209-215.
Laine and Hayem (1981), Biochem. et Biophys. Acta 668:429-438.
Lindmark et al. (1989), Biochim. et Biophys. Acta 997:90-95.
Mast et al. (1991), Biochemistry 30:1723-1730.
Morii and Travis (1983), Biochem. Biophys. Res. Commun. 111:438-443.
Nelson and Siman (1990), J. Biol Chem. 265:3836-3843.
Pasternack et al. (1989), Am. J. Pathol. 135:827-834.
Potempa et al. (1991), J. Biol. Chem. 266:21482-21487.
Richards et al (1991), EMBO J. 10:297-303.
Rubin et al. (1990), J. Biol. Chem. 265:1199-1207.
Travis and Morii (1981), Meth. Enzymol. 80:765-771.
Wick et al. (1987), Virchows Archiv A 411:23-32.

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