Novel process for producing cephalosporins

Details Novel process for producing cephalosporins Novel process for producing cephalosporins

1984-09-19

1986-09-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540225, 540227, 540228, C07D50122, C07D50124, C07D50136

Patent

active

046148191

ABSTRACT:
This invention relates to a novel process for producing a useful cephalosporin which comprises reacting a thiolo ester compound with a 7-aminocephalosporin in the presence of boron trifluoride or a complex compound thereof. This process enables the cephalosporin to be produced with a high purity in a high yield.

REFERENCES:
patent: 4299829 (1981-11-01), Kamiya
patent: 4307116 (1981-12-01), Farge et al.
patent: 4385181 (1983-05-01), Farge et al.
patent: 4425341 (1984-01-01), Takaya et al.
patent: 4460582 (1984-07-01), Naylor
patent: 4489072 (1984-12-01), Sadaki et al.
Fieser "Reagents for Organic Synthesis", vol. 6, 1977, p. 67.

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