Amino-substituted flavans useful as anti-viral agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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549404, 424283, C07D31160

Patent

active

044619073

ABSTRACT:
Novel compounds of formula (IID) ##STR1## wherein either both X and Y represent groups independently selected from amino and lower alkylamino, or one of X and Y represents a group selected from amino and lower alkylamino and the other of X and Y represents a hydrogen atom have been found to be active against rhinoviruses and other viruses. Processes for producing these compounds include reduction of flavanone derivatives or of flavenes. Alternatively, reductive cyclization of chalcones affords the compounds. These may also be prepared by condensation of o-(substituted methyl)phenols with styrene derivatives.
Pharmaceutical formulations and methods for the administration of the compounds are described.

REFERENCES:
patent: 3450717 (1969-06-01), Kramer et al.
Terrell et al., J. Antimicrob. Chemo., 9, 340 (1982).

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