Pyrrolidine 2-one derivatives

Details Pyrrolidine 2-one derivatives Pyrrolidine 2-one derivatives

1980-07-28

1984-07-24

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548543, 548544, 548517, 424274, C07D207273, C07D40712, A61K 31404

Patent

active

044619065

ABSTRACT:
1-Substituted-2-pyrrolidinones of the formula ##STR1## wherein one of R.sup.1, R.sup.2 and R.sup.3 represents hydroxy and the remaining substituents represent hydrogen,
are capable of counteracting cerebral insufficiency produced experimentally in animal tests. They can be used therapeutically in the control or prevention of cerebral insufficiency or in the improvement of intellectual capacity. They can be manufactured from novel intermediates and can be processed to provide medicaments.

REFERENCES:
patent: 4239770 (1980-12-01), Kyburz et al.
Giurgea et al., "Prog. Neuro-psychopharmac", vol. 1, pp. 235-247, (1977).
Faragher et al., Chem. Abst., vol. 86, (1977), 5393r.
1976 Merck Index #7282 Merc. & Co., Rahway, N.J., listed alphabetically under "Piracetam".

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