Process for the asymmetric synthesis of chiral indoline-2-carbox

Details Process for the asymmetric synthesis of chiral indoline-2-carbox Process for the asymmetric synthesis of chiral indoline-2-carbox

1985-02-11

1986-09-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562434, 562438, 562452, 562456, C07D20942

Patent

active

046148060

ABSTRACT:
Disclosed herein is a process for producing an asymmetric indoline-2-carboxylic acid of the structural Formula: ##STR1## wherein X is hydrogen, bromine, chlorine, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, which comprises:

REFERENCES:
patent: 4060626 (1977-11-01), Hrstka et al.
D. Hepburn et al., Chemical Abstracts 82:3698n (1975).
Houlihan, ed., The Chemistry of Heterocyclic Compounds, vol. 25, part 1, pp. 396-399 (Wiley Interscience, New York 1972).
Hudson, C. B. and Robertson, A. V., Australian Journal of Chemistry, 20, 1935-41 (1967).
Stanton et al., Journal of Medicinal Chemistry, 26, 1267-77, 1268 (1983).
Corey et al., Journal of the American Chemical Society, 2476-2488, at 2480 (1970).
Vincent et al., Tetrahedron Letters, vol. 23, No. 16, pp. 1677-1680 at 1678 (Apr./May, 1982).

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