Hybrid cell line for producing monoclonal antibody to a human T

Details Hybrid cell line for producing monoclonal antibody to a human T Hybrid cell line for producing monoclonal antibody to a human T

1982-10-04

1986-09-30

Warren, Charles F.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 435948, 436548, 935104, 935110, C12N 500, C12P 2100, C12R 191, G01N 3354

Patent

active

046147209

ABSTRACT:
Hybrid cell line for production of monocloral antibody to an antigen found on essentially all normal human T cells and on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF.sub.1 mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

REFERENCES:
patent: 4364937 (1982-12-01), Kung et al.
Levy, Ronald, et al., "A Human Thymus-Leukemia Antigen Defined by Hybridoma Monoclonal Antibodies", Proceedings of the Natl. Academy of Sci. U.S.A., 76, Dec. '79, pp. 6552-6556.
Engleman, E. G., et al., "Studies of a Human T Lymphocyte . . . ", Proceedings of the Natl. Academy of Science, U.S.A., 78, Mar. '81, pp. 1791-1795.

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