Synthesis and use of amino acid fluorides as peptide coupling re

Details Synthesis and use of amino acid fluorides as peptide coupling re Synthesis and use of amino acid fluorides as peptide coupling re

1995-06-06

1998-05-12

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

530333, 530334, 530335, 530336, 530337, 530338, 544334, 546186, 5483001, 5483401, 5483431, 5483471, 548495, 548496, 548497, 548527, 548530, C07C25714, C07C25718, C07D23302, C07D20702

Patent

active

057507678

ABSTRACT:
The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting group

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