Process for the preparation of aromatic bromomethyl compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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549 49, 570183, C07D33356, C07D33352, C07C 2204

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active

057507287

ABSTRACT:
Aromatic bromomethyl compounds play a major role in the synthesis of active substances. They can be obtained in particularly pure form by the free-radical bromination of aromatic methyl compounds in the solvent chlorobenzene.

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patent: 5420300 (1995-05-01), Dormoy
McMurry, "Organic Chemistry", 2nd. Ed., (1988), pp. 553-554.
Morrison & Boyd, "Organic Chemistry", 4th Ed., (1983), pp. 641-643.
Korke et al, "Bromination of Methyl Groups Bonded to Aromatic Rings", CA 114:81213, (1991).
Vaccher, Claud et al Synthetic Communication, Bd. 23, Nr. 5, 1993, pp. 671-679.
Sugiura Tsuneyuki et al, SYNLETT, Bd. 6, Jun. 1992, Stuttgart De pp. 531-533.
"Bromination--Introducing Bromine Into An Organic Compound By Addition or Substitution", Rompps Chemie-Lexikon, Achte, neubearbeitete und erweiterte Auflage, Dr. Otto-Albrecht Neumuller, Franckh'sche Verlagshandlung, W. Keller and Co., Stuttgart, 1979, p. 521.

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