Process for producing N-acyl-hydroxy aromatic amines

Details Process for producing N-acyl-hydroxy aromatic amines Process for producing N-acyl-hydroxy aromatic amines

1984-06-08

1985-06-18

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C10312, C07C10322

Patent

active

045242178

ABSTRACT:
N-acyl-hydroxy aromatic amines, e.g. N-acetyl-para-aminophenol (APAP), are prepared by reacting a hydroxy aromatic ketone, e.g. 4-hydroxyacetophenone, with a hydroxylamine salt and a base to obtain the ketoxime of the ketone, e.g. 4-hydroxyacetophenone oxime, and then subjecting the ketoxime to a Beckmann rearrangement in the presence of a catalyst to form the N-acyl-hydroxy aromatic amine.

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