Azepinone compounds useful in the inhibition of ACE and NEP

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

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514212, 514 79, 540524, 540528, 540487, C07C22312, C07C40506, A61K 3155

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057506876

ABSTRACT:
Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: A is ##STR2## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.

REFERENCES:
patent: 3856798 (1974-12-01), Meyer et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4186200 (1980-01-01), Kubo et al.
patent: 4192945 (1980-03-01), Ondetti
patent: 4225495 (1980-09-01), Ondetti
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4339600 (1982-07-01), Ondetti et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4409146 (1983-10-01), Thorsett et al.
patent: 4410520 (1983-10-01), Watthey
patent: 4415496 (1983-11-01), Harris et al.
patent: 4432971 (1984-02-01), Karanewsky et al.
patent: 4432972 (1984-02-01), Karanewsky et al.
patent: 4460579 (1984-07-01), Karanewsky
patent: 4465679 (1984-08-01), Huang et al.
patent: 4470988 (1984-09-01), Watthey
patent: 4473575 (1984-09-01), Watthey
patent: 4477464 (1984-10-01), Slade et al.
patent: 4512924 (1985-04-01), Attwood et al.
patent: 4537885 (1985-08-01), Watthey
patent: 4539150 (1985-09-01), Katakami et al.
patent: 4548932 (1985-10-01), Sugihara et al.
patent: 4575503 (1986-03-01), Watthey
patent: 4584294 (1986-04-01), Ruyle
patent: 4587050 (1986-05-01), Harris et al.
patent: 4587238 (1986-05-01), Harris et al.
patent: 4594341 (1986-06-01), Cheung et al.
patent: 4617301 (1986-10-01), Patchett et al.
patent: 4629787 (1986-12-01), Harris et al.
patent: 4680392 (1987-07-01), Harris et al.
patent: 4699905 (1987-10-01), Yanagisawa et al.
patent: 4711884 (1987-12-01), Karanewsky
patent: 4722810 (1988-02-01), Delaney et al.
patent: 4734410 (1988-03-01), Yanagisawa et al.
patent: 4749688 (1988-06-01), Haslanger et al.
patent: 4801609 (1989-01-01), Haslanger et al.
patent: 4824832 (1989-04-01), Flynn et al.
patent: 4857520 (1989-08-01), Urbach et al.
patent: 4873235 (1989-10-01), Parsons et al.
patent: 4879309 (1989-11-01), Doll et al.
patent: 4963539 (1990-10-01), Delaney
patent: 4973585 (1990-11-01), Flynn et al.
patent: 5061710 (1991-10-01), Haslanger et al.
patent: 5075302 (1991-12-01), Neustadt
patent: 5098934 (1992-03-01), Vevert et al.
patent: 5190974 (1993-03-01), Clemence et al.
patent: 5208236 (1993-05-01), Neustadt
patent: 5223516 (1993-06-01), Delaney et al.
patent: 5225401 (1993-07-01), Seymour
patent: 5232920 (1993-08-01), Neustadt
patent: 5238924 (1993-08-01), Smith
patent: 5262436 (1993-11-01), Haslanger et al.
patent: 5362727 (1994-11-01), Robl
patent: 5366973 (1994-11-01), Flynn et al.
patent: 5508272 (1996-04-01), Robl
Sreenivasan, U. et al J. Med. Chem. 36, 256-263 (1993).
Adams et al., Synthetic Communications, vol. 18, 2225-2231 (1988).
Attwood et al., FEBS Letters, vol. 165, pp. 201-206 (1984).
Attwood et al., J. Chem. Soc. Perkin Trans I (1986) pp. 1011-1019.
Bolos et al., J. Org. Chem., 57, 3535-3539 (1992).
Bolos et al., Tetrahedron, vol. 48, pp. 9567-9576 (1992).
Boyer, T. D. "Cirrhosis of the Liver and Its Major Sequelae" in: Wyngaarden, J. B. et al., Cecil Textbook of Medicine, vol. 1 (Saunders Co., 1992) pp. 786-789.
Chackalamannil et al., Bioorganic & Medicinal Chemistry Letters, vol. 2, pp. 1003-1006 (1992).
Das et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 2193-2198 (1994).
Delaney et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1783-1788 (1994).
Dussaule et al., Jour. of Clinical Endocrinology and Metabolism, vol. 72, pp. 653-659 (1991).
Fernandez-Cruz, The Lancet, Dec. 21/28, pp. 1439-1440 (1985).
Flynn et al., J. Med. Chem., 36, pp. 2420-2423 (1993).
Flynn, Tetrahedron Letters, vol. 31, pp. 815-818 (1990).
Fobian et al., 206th Meeting of the Amer. Chem. Society, Aug. 1993 Abstr. ORG 297.
Fyhrquist et al., The Lancet, Dec. 21/28, p. 1439 (1985).
Hanau et al., 206th Meeting of the Amer. Chem. Society, Aug. 1993 Abstr. ORG 298.
Itoh et al., Chem. Pharm. Bull., vol. 34, pp. 1128-1147, 2078-2089 (1986).
Laffi et al., Gastroenterology, vol. 96, pp. 167-177 (1989).
Moeller et al., Tetrahedron Letters, vol. 33, pp. 6041-6044 (1992).
Naming and Indexing of Chemical Substances for Chemical Abstracts, 1987 Index Guide, Section 203.
Natoff et al., Drugs Of the Future, vol. 12, pp. 475-483 (1987).
Parsons et al., Biochem and Biophysical Research Comm. 117, pp. 108-113 (1983).
Robl et al., Bioorganic & Medicinal Chem. Letters, vol. 4, pp. 1795-1800 (1994).
Robl et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1789-1794, 2055-2060 (1994).
Robl et al., J. Am. Chem. Soc., 116, pp. 2348-2355 (1994).
Robl, Tetrahedron Letters, vol. 35, pp. 393-396, 1393-1396 (1994).
Slade et al., J. Med. Chem., 28, pp. 1517-1521 (1985).
Smith et al., Biochemistry, vol. 14, pp. 766-771 (1975).
Thorsett et al., J. Med. Chem., 29, pp. 251-260 (1986).
Thorsett, Actual Chim. Ther., vol. 13, pp. 257-268 (1986).
Watthey et al., J. Med. Chem., 28, pp. 1511-1516 (1985).
Yanagisawa et al., J. Med. Chem., 30, pp. 1984-1991 (1987).
Yanagisawa et al., J. Med. Chem., 31, pp. 422-428 (1988).

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