Anhydrous amine cleavage of oligonucleotides

Details Anhydrous amine cleavage of oligonucleotides Anhydrous amine cleavage of oligonucleotides

1996-11-22

1998-05-12

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, C07H 102, C07H 2100

Patent

active

057506728

ABSTRACT:
A method for recovering synthesized oligonucleotides from a solid support that includes the step of incubating the solid support with an anhydrous amine reagent under conditions suitable to cleave and deprotect the oligonucleotide. The cleaved and deprotected oligonucleotide will be substantially insoluble in the reagent and/or will exhibit preferential affinity for the support. Reagent kits for use in such a method, and cleaved, deprotected oligonucleotides prepared by means of such a method are provided.

REFERENCES:
patent: 5348868 (1994-09-01), Reddy et al.
patent: 5686599 (1997-11-01), Tracz
Reddy et al Tetrahedron Letters, 35(25):4311-4314.

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