5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and thei

Details 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and thei 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and thei

1983-02-07

1985-06-18

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546288, 546298, 560170, C07D21357, C07D21350, A61K 3144

Patent

active

045241490

ABSTRACT:
4-R.sub.2 -5-(Lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinones (I), useful as cardiotonics, where R.sub.2 is hydrogen or methyl, are prepared by reacting 2-(lower-alkanoyl)-1-(lower-alkyl)ethenamine (II) with lower-alkyl 2-propynoate or 2-butynoate respectively or by hydrolyzing 4-R.sub.2 -5-(lower-alkanoyl)-6-(lower-alkyl)-1,2-dihydro-2-oxonicotinonitrile (III), Q is CN) or corresponding 4-R.sub.2 -5-(lower-alkanoyl)-6-(lower-alkyl)-1,2-dihydro-2-oxonicotinamide to produce the corresponding 5-(lower-alkanoyl)-6-(lower-alkyl)-1,2-dihydro-2-oxonicotinic acid and decarboxylating said substituted nictotinic acid to produce I. Also disclosed and claimed are cardiotonic uses of 3-Q-4-R.sub.2 -5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinones where Q is hydrogen or cyano and R.sub.2 is hydrogen or methyl (III). Also shown and claimed is methyl 4-acetyl-5-amino-2,4-hexadienoate or acid-addition salt thereof, useful as intermediate or cardiotonic.

REFERENCES:
patent: 3654291 (1972-04-01), Witzel et al.
patent: 4412077 (1983-10-01), Lesher et al.
Sunthankar et al., Chemical Abstracts, vol. 80, No. 23, Abst. No. 133,202r, June 10, 1974.
Sunthankar et al., [Indian J. of Chem. 11, 1315-16, (1973)].
Kato et al., [J. Heterocyclic Chem. 18, 603-606, (1981)].
Kato et al., [Chem. Pharm. Bull. 17, 2411-2416, (1969)].
Fujita, [Chem. Pharm. Bull. 23, 501-506, (1975)].
Krasnaya et al., [C.A. 87, 68099r, (1977)].

Affiliated with

Also associated with

Rating

5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and thei does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and thei, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and thei will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-979843