Process for preparing mammalian T cell growth factor P40

Details Process for preparing mammalian T cell growth factor P40 Process for preparing mammalian T cell growth factor P40

1995-05-23

1998-05-12

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4352401, 4352402, 530351, 530412, 530416, 530417, C07K 1454, C07K 118, C07K 120

Patent

active

057503770

ABSTRACT:
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.

REFERENCES:
patent: 4390623 (1983-06-01), Frabricius et al.
patent: 4401756 (1983-08-01), Gillis
patent: 4623622 (1986-11-01), Anderson
patent: 5157112 (1992-10-01), Van Snick et al.
patent: 5208218 (1993-05-01), Van Snick et al.
patent: 5414071 (1995-05-01), Yang et al.

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