Human and mouse very low density lipoprotein receptors and metho

Details Human and mouse very low density lipoprotein receptors and metho Human and mouse very low density lipoprotein receptors and metho

1993-11-08

1998-05-12

Stanton, Brian R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 435 701, 435 703, 435 711, 435243, 4353201, 435325, 435410, 536 231, 536 235, 536 241, 935 22, 935 33, C07H 2102, C12N 500, C12N 1512, C12P 2106

Patent

active

057503672

ABSTRACT:
Methods of treating diseases or conditions, characterized by elevated serum lipoprotein levels, by providing elevated levels of a VLDL receptor in an animal, e.g., a human are set forth. Such receptors aid in removal of circulating VLDL and related lipoproteins, and thus decrease the risk of developing coronary diseases or conditions or decrease the severity of such diseases or conditions. Clones of human and mouse VLDL receptor which can be used in the invention are also provided. Vectors for the expression of VLDL receptors, stably transfected and transformed cells and transgenic animals are also provided.

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