Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1993-05-28
1998-05-12
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
4352523, 4353201, 435 694, 536 235, C17K 1519
Patent
active
057503656
ABSTRACT:
The present invention relates to novel newt aFGF cDNA and sequence, newt FGFR1 cDNA and sequence, newt FGFR2 cDNA and sequence, newt FGFR3 cDNA and sequence, newt KGFR cDNA and sequence, and CHO-KL cell line (KPTr2-2) expressing newt KGFR. Mutant cell lines (Tr31-5-1 and Tr33-1-2) that become non-responsive to aFGF stimulation are used to differentiate biological activities among different forms of aFGF and other FGF proteins. These novel sequences and cell lines substantially enhance the availability of newt acidic fibroblast growth factor and are useful for producing compositions for promoting growth and/or wound healing.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
Wozney, Methods in Enzymol 182:738-749 (1990).
Krust et al. EMBO J. 5:891-897 (1986).
Gospodarowicz Methods in Enzymol 147:106-119 (1987).
Basilico et al. Adv. Cancer Res. 59:115-165 (1992).
Gospodarowicz et al. Endocrine Rev 8:95-114 (1987).
Jimenez-Gallejo et al. Science 230:1385-1388 (1985).
Gautsehi-Sova et al. Biochem Biophys Res Comm 140:874-880 (1986).
Basilico et al., 1992, The FGF family of growth factors and oncogenes. Adv. Cancer Res. 59:115-165.
Jaye et al., 1986, Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosomal localization. Science 23:541-545.
Wang et al., 1989, Cloning of the gene coding for human class I heparin-binding growth factor and its expression in fetal tissue. Mol. Cell. Biol. 9:2387-2395.
Abraham et al., 1986, Human basic fibroblast growth factor: nucleotide sequence and genomic organization. EMBO J. 5:2523-2528.
Dickson et al., 1987, Potential oncogene product related to growth factors. Nature 326-833.
Acland et al., 1990, Subcellular fate of int-2 oncoprotein is determined by choice of initiation codon. Nature 343:662-665.
Delli-Bovi et al., 1987, An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family, Cell 50:729-737.
Taira et al., 1987, cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc. Natl. Acad. Sci. USA 84:2980-2984.
Zhan et al., 1988, The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Mol. Cell. Biol. 8:3487-3495.
deLapeyriere et al., 1990, Structure, chromosome mapping, and expression of the murine FGF-6 gene. Oncogene 5:823-831.
Finch et al., 1989, Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245:752-755.
Tanaka et al., 1992, Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc. Natl. Acad. Sci. USA 89:8928-8932.
Werner et al., 1992, Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc. Natl. Acad. Sci. USA 89:6896-6900.
Johnson et al., 1993, Structural and functional diversity in the FGF receptor multigene family, Adv. Cancer Res. 60:1-41.
Ruta et al., 1989, Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG). Proc. Natl. Acad. Sci. USA 86:8722-8726.
Dionne et al., 1990, Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factor. EMBO J. 9:2685-2692.
Johnson et al., 1990, Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol. Cell. Biol. 10:4728-4736.
Kornbluth et al., 1988, Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. Mol. Cell. Biol. 8:5541-5544.
Keegan et al., 1991, Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc. Natl. Acad. Sci. USA 88:1095-1099.
Partanen et al., 1991, FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 10:1347-1354.
Williams et al, 1988, The immunoglobulin superfamily-domains for cell surface recognition. Ann. Rev. Immunol. 6:381-405.
Mansukhani et al., 1990, A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF. Proc. Natl. Acad. Sci. USA 87:4378-4382.
Fujita et al., 1991, The expression of two isoforms of the human fibroblast growth factor receptor (flg) is directed by alternative splicing. Biochem. Biophys. Res. Comm. 174:946-951.
Champion-Arnaud et al., 1991, Multiple mRNAs code for proteins related to the BEK fibroblast growth factor receptor. Oncogene 6:979-987.
Eisemann et al., 1991, Alternative splicing generates at least five different isoforms of the human basic-FGF receptor. Oncogene 6:1195-1202.
Johnson et al., 1991, The human fibroblast growth factor receptor genes: A common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol. Cell. biol. 11:4627-4634.
Yayon et al., 1992, A confined variable region confers ligand specificity on fibroblast growth factor receptors: Implications for the origin of the immunoglobulin fold. EMBO J. 11:1885-1890.
Miki et al., 1991, Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science 251:72-75.
Miki et al., 1992, Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene. Proc. Natl. Acad. Sci. USA 89:246-250.
Mansukhani et al., 1992, Characterization of the murine BEK fibroblast growth factor (FGF) receptor: Activation by three members of the FGF family and requirement for heparin. Proc. Natl. Acad. Sci. USA 89:3305-3309.
Whitman et al., 1989, Growth factors in early embryogenesis. Annu. Rev. Cell Biol. 5:93-117.
Hebert et al., 1990, Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. Dev. Biol. 138:454-463.
Niswander et al., 1992, FGF-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development 114:755-768.
Tannahill et al., 1992, Development expression of the Xenopus int-2(FGF-3) gene: Activation by mesodermal and neural induction. Development 115:696-702.
Mescher et al, 1979, Mitogenic effect of a growth factor derived from myelin on denervated regenerates of newt forelimbs. J. Exp. Zool. 207:497-503.
Gospodarowicz et al., 1980, Fibroblast growth factor and the control of vertebrate regeneration and repair. Ann. N.Y. Acad. Sci. 339:151-174.
Boilly et al., 1991, Acidic fibroblast growth factor is present in regenerating limb blastemas of axolotls and binds specifically to blastema tissue. Dev. Biol. 145:302-310.
Orr-Urtreger et al., 1991, Development expression of two murine fibroblast growth factor receptors, flg and bek. Development 113:1419-1434.
Peters et al., 1992, Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 114:233-243.
Bunnag et al., 1991, Transformed phenotype conferred to NIH/3T3 cells by ectopic expression of heparin-binding growth factor 1/acidic fibroblast growth factor. In Vitro Cell. Dev. Biol. 27A:89-96.
Chiu et al., 1990, Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene 5:755-762.
Chiu Ing Ming
Poulin Matthew L.
The Ohio State University Research Foundation
Ulm John
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