Process for preparing penicillins

Details Process for preparing penicillins Process for preparing penicillins

1977-12-12

1978-11-28

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D 4912, C07D 4904

Patent

active

041275713

ABSTRACT:
A process for preparing penicillins, in which 6APA is treated with a polar solvent, then with an organic base to give a mixture which is cooled at a temperature lower than -25.degree. C. A cyclic derivative of boron is added to the mixture and the temperature is increased to about 0.degree. C.
An intermediate compound is formed which by treatment first with an acylating agent and then with a mixture of water and alcohol provides a solution containing the penicillin.

REFERENCES:
patent: 3479338 (1969-11-01), Adams

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