Mevinic acid derivatives

Details Mevinic acid derivatives Mevinic acid derivatives

1989-11-13

1992-12-22

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514548, 514529, 514460, 5142278, 5142315, 5142375, 514255, 514315, 514330, 514354, 514397, 514400, 514422, 514423, 549292, 560119, 560256, 548517, 548535, 5483111, 5483381, 546221, 546268, 546326, 544374, 544149, 544172, 544 60, 544 59, A61K 31365, C07C 6974, C07D30930

Patent

active

051734877

ABSTRACT:
Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, is exhibited by a compound of the formula ##STR1## m is 0 to 3; R is selected from:

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Terohara et al. "M-4 and iso M-4 derviatives and compositions containing them" CA 98 215415y (1983).
F. M. Singer et al., "New Inhibitors of in vitro Conversion of Acetate and Mevalonate to Cholesterol", Proc. Soc. Exper. Biol. Med., 102, 370 (1959).
F. H. Hulcher, "Inhibition of Hepatic Cholesterol Biosynthesis by 3,5-Dihydroxy--3,4,4-trimethylvaleric Acid and its Site of Action," Arch. Biochem. Biophys., 146, 422 (1971).
A. G. Brown et al., "Crystal and Molecular Structure of Compactin, a New Antifungal Metabolite from Penicillium Brevicompactum", J. Chem. Soc. Perkin I. 1165-1170 (1976).

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