Desulfurization of penicillins to prepare azetidinones

Details Desulfurization of penicillins to prepare azetidinones Desulfurization of penicillins to prepare azetidinones

Filed on

1982-05-17

Date issued

1984-07-24

Examiner

Berch, Mark L.

Patent Class

Chemistry of carbon compounds

SubClass

Miscellaneous organic carbon compounds

SubSubClass

C-metal

Other Related Categories

2602454, 2603309, 546275, C07D20508, C07D40304, C07D40112, C07D40312

Type

Patent

Status

active

Patent number

044617267

Description

ABSTRACT:
A process for the Raney nickel desulfurization of penicillins is described. In the process of the invention, amino penicillanic acid or derivatives thereof are reacted with Raney nickel under controlled conditions of temperature and time to yield azetidinones which are useful as intermediates for the synthesis of monocyclic beta-lactam antibiotics.

REFERENCES:
Whitesitt et al., Tetrahedral Letters, 1978, 1737.
Duranti et al., Synthesis, 1977, p. 494.
Van Heyninger et al., J. Med. Chem., 11, 933, (1968).
Wolfe et al., Chem. Comm., 1970, p. 833.

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