Reagents and process for synthesis of oligonucleotides containin

Details Reagents and process for synthesis of oligonucleotides containin Reagents and process for synthesis of oligonucleotides containin

1997-08-26

2000-09-12

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 2534, C07H 1910, C07H 1920, C07H 102

Patent

active

061179922

ABSTRACT:
The invention provides new methods for synthesizing oligonucleotides containing at least one, and preferably all phosphorodithioate internucleoside linkages with less than 5% phosphoromonothioate contamination. This level of purity in the synthesis of phosphorodithoates has previously been very difficult to achieve with all existing methods. The invention further provides phosphorothioamidite nucleoside synthons comprising a sulfur protecting group that is stable under normal oligonucleotide synthesis conditions.

REFERENCES:
Dahl et al. ACTA Chem. Scand. 43: 896-901, 1989.
Dahl et al. Tetrahedron Lett. 31: 3489-3492, 1990.
Bjergarde et al. Nucl. Acids Res. 19: 5843-5850, 1991.
Wiesler et al. J. Org. Chem. 61: 4272-4281, 1996.

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