Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-06-14
1992-12-22
Waddell, Frederick E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
43524027, 435 723, 53038815, 5303913, 5303888, 424 9, 424 858, A61K 3766, C12H 500, C61K 3514
Patent
active
051732920
ABSTRACT:
This invention provides a composition useful for diagnosing cancer which specifically recognizes a galactosyl-globoside. Preferably, the composition is a monoclonal antibody which specifically recognize the galactosyl-globoside antigen, gal-Gb4.
Additionally, the present invention provides two hybridoma cell lines, designated J309 and D579, which produce monoclonal antibodies that specifically recognize gal-Gb4.
The invention also provides a method of diagnosing a carcinoma which comprises contacting a sample from a human subject with a composition which specifically recognizes a galactosyl-globoside antigen and is labeled with a detectable moiety, under suitable conditions so as to form a detectable complex. The amount of formed complex is then quantified and correlated with values obtained from subjects devoid of carcinomas.
Another aspect of the invention provides a method of treating carcinoma which comprises administering an effective amount of galactosyl-globoside or an analog thereof and a pharmaceutically carrier to stimulate the body production of antibodies.
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Young, et al.; Journal of Biological Chemistry, vol. 256 (21), pp. 10967-10972 (1981).
Bremer et al., Journal of Biological Chemistry, vol. 259 (23) pp. 14773-14777 (1984).
Kannagi et al.; Journal of Biological Chemistry, vol. 258 (14) pp. 8934-8942 (1983).
Shevinsky et al.; Cell, vol. 30, pp. 697-706 (1982).
Furukawa Koichi
Lloyd Kenneth O.
Old Lloyd J.
Schrump David S.
Yamaguchi Hiroshi
Criares T. J.
Sloan-Kettering Institute for Cancer Research
Waddell Frederick E.
White John P.
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