Thiazole, isothiazole, oxazole and isoxazole compounds

Details Thiazole, isothiazole, oxazole and isoxazole compounds Thiazole, isothiazole, oxazole and isoxazole compounds

1978-09-11

1980-04-08

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424272, 548186, 548187, 548189, 548202, 548204, 548205, 548213, 548214, 548225, 548228, 548229, 548235, 548236, 548243, 548247, C07D27720

Patent

active

041973054

ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitrometylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)ethyl)isothiour eido]propane. The compounds of this invention are inhibitors of H-2 histamine receptors.

REFERENCES:
patent: 3917626 (1975-11-01), Edwards
patent: 3968227 (1976-01-01), Durant et al.
patent: 4034101 (1977-07-01), Durant et al.
patent: 4062967 (1977-12-01), Durant et al.
patent: 4070472 (1978-01-01), Durant et al.
patent: 4137319 (1979-01-01), Durant et al.
Conant et al., The Chemistry of Organic Compounds, p. 264 (1939), N.Y., Macmillan.

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