Potentiation of antihypertensive effect of ace inhibitors

Details Potentiation of antihypertensive effect of ace inhibitors Potentiation of antihypertensive effect of ace inhibitors

1987-10-19

1990-10-09

Willis, Prince E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 3155, C07D2236

Patent

active

049621050

ABSTRACT:
Disclosed is a method of enhancing the antihypertensive effect of an angiotensin converting enzyme inhibitor which comprises the administration to mammals of an effective antihypertensive potentiating amount of 1-(7-carboxyheptyl)-3-methyl-2-(3-pyridyl)-indole, 1-methyl-2-(3-pyridyl)-3-)5-carboxypentyl)-5-chloroindole, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising the 2-(3-pyridyl)-indole derivatie in combination with an angiotensin converting enzyme inhibitor.

REFERENCES:
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patent: 4478842 (1984-04-01), Renfroe
patent: 4511573 (1985-06-01), Renfroe
patent: 4575503 (1986-03-01), Watthey
patent: 4600534 (1986-01-01), Bach et al.
Chiba, et al., Abstract 07-18 Kyoto Conference on Prostoglandins, Nov. 25-28 (1984).
Weir et al., Am. J. Hypertension, vol. 1, No. 3, part 2, (1989), Abstract No. 1014, p. 69A.
USAN 1989, p. 444.
Bitterman et al., J. Pharmacology Exp. Ther., vol. 242, pp. 8-14, (1987).
Cross et al., Annual Reports in Medicinal Chemistry, vol. 22, 95-105 (1987).
Cardiovascular Drugs and Therapy, vol. 1, No. 3, p. 223 (10/87).

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