Heterocyclic glycerol derivatives and their use as anti-hyperten

Details Heterocyclic glycerol derivatives and their use as anti-hyperten Heterocyclic glycerol derivatives and their use as anti-hyperten

1988-03-24

1990-10-09

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 89, 514 95, 514 96, 546 22, 548112, 548113, C07F 96539, C07F 96541, A61K 31425

Patent

active

049620967

ABSTRACT:
A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (--(Q).sub.l -- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R.sup.5, R.sup.6 and R.sup.7 is hydrogen, lower alkyl, aryl or aralkyl.

REFERENCES:
patent: 4408052 (1983-10-01), Hozumi et al.
patent: 4426525 (1984-01-01), Hozumi et al.
patent: 4649203 (1987-03-01), Nojima et al.
patent: 4650791 (1987-03-01), Nomura et al.
patent: 4710579 (1987-12-01), Nojima et al.
patent: 4900731 (1990-02-01), Wissner et al.

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