Process for obtaining nerve growth factor

Details Process for obtaining nerve growth factor Process for obtaining nerve growth factor

1979-02-05

1983-10-04

Rosen, Sam

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 95, 424177, C07G 700, A61K 3700

Patent

active

044077440

ABSTRACT:
A new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000.

REFERENCES:
Kuzmicheva-Chem. Abst. vol. 89 (1978), p. 125,424k.
Konovalov et al.-Chem. Abst., vol. 82 (1975), p. 53569s.
Stach et al.-Chem. Abst., vol. 87 (1977), p. 163630r.
Konovalov et al.-Tsitologiya, vol. 16, No. 10 (1974), pp. 1268-1274 (Translation of record).

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