Method of making barbituric acid derivatives

Details Method of making barbituric acid derivatives Method of making barbituric acid derivatives

1976-04-30

1977-06-14

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D23962

Patent

active

040296628

ABSTRACT:
There is disclosed an improved process for the preparation of 1,3-bis(alkoxyalkyl)- and 1,3-bis(benzyloxyalkyl)-5,5-disubstituted barbituric acid derivatives, such as 1,3-bis(methoxymethyl)phenobarbital, by reacting e.g., phenobarbital, preferably, a multiple molar excess of dimethoxymethane and an at least equimolar amount of anhydrous stannic chloride based on the amount of phenobarbital.

REFERENCES:
patent: 3635980 (1972-01-01), Vida et al.
patent: 3784547 (1974-01-01), Samour
patent: 3947443 (1976-03-01), Vida
Yardley et al., "Introduction of the Methoxymethyl Ether Protecting Group," Synthesis, Apr. 1976, pp. 244.

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