Chemistry: physical processes – Physical processes – Crystallization
Patent
1977-09-23
1980-04-08
Marantz, Sidney
Chemistry: physical processes
Physical processes
Crystallization
250574, 356 39, 356246, 422 73, 422104, 424 12, G01N 3316, G01N 2124
Patent
active
041970888
ABSTRACT:
A method for qualitative and quantitative determination of agglutination in immunoreactive systems, and for determining the concentration of the immunoreactive components of such system, which method comprises introducing a fluid biological test specimen and a reagent therefor (e.g., latex spheres) into a reaction zone in an image cell and evenly mixing and incubating the mixture thereby forming agglutinated particles. The reaction zone is then transilluminated and the light beams transmitted therethrough are imaged on an image sensor. Dark areas are formed on the surface of the image sensor which are measured, preferably electronically. This procedure is repeated for a reference specimen and the total dark imaged area is compared with the total dark area obtained for the unknown specimen for qualitative determination.
In order to obtain the concentration of the immunoreactive component in the unknown specimen, the foregoing procedure is repeated for at least two specimens with known antibody concentrations, one of which may be a negative control. The concentration of the immunoreactive component of the unknown sample is then determined from the total dark imaged area thereof and the relationship between the total dark imaged areas of the known specimen and their respective concentrations.
REFERENCES:
patent: 3395210 (1968-07-01), Lenahan et al.
patent: 3463614 (1969-08-01), Leslie
patent: 3520609 (1970-07-01), Lion
patent: 3617222 (1971-11-01), Matte
patent: 3770380 (1973-11-01), Smith
patent: 3803299 (1974-04-01), Nouel
patent: 3819271 (1974-06-01), Beug
patent: 3826613 (1974-07-01), Parikh et al.
patent: 3905767 (1975-09-01), Morris
patent: 3915640 (1975-10-01), Turner et al.
patent: 3932141 (1976-01-01), Beall et al.
patent: 3967901 (1976-07-01), Rodriguez
patent: 3984533 (1976-10-01), Uzgiris
patent: 3990851 (1976-11-01), Gross
patent: 4003988 (1977-01-01), Hoff et al.
patent: 4027973 (1977-06-01), Kaye
patent: 4043669 (1977-08-01), Gehatia
patent: 4050895 (1977-09-01), Hardy
patent: 4052010 (1977-10-01), Baker et al.
patent: 4080264 (1978-03-01), Cohen
patent: 4097149 (1978-06-01), Aladjem
patent: 4118192 (1978-10-01), Sawai
patent: 4136953 (1979-01-01), Klein
Acker Jesse L.
Meserol Peter M.
Akro-Medic Engineering, Inc.
Marantz Sidney
LandOfFree
Method for qualitative and quantitative determination of immunol does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for qualitative and quantitative determination of immunol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for qualitative and quantitative determination of immunol will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-971776