Leukotriene B.sub.4 antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514330, 514423, 514539, 514559, 546226, 548539, 554111, 560 42, 562451, A61K 3139, A61K 3121, C07C 5911, C07C 69612

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active

054399378

ABSTRACT:
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;

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Appleton, R. A. et al. Antagonists of Slow Reacting Substance of Anaphylaxis, Synthesis of a Series of Chromone-2-Carboxylic Acids, Journal of Medicinal Chemistry, 20, 371-379 (1977).
Searle, G.D. & Co. Benzopyran Antimetabolites, Chem. Abstracts, 103, 699, Abstract No. [160389g] (1985).
Antagonists of SRS-A and Leukotrienes, Chem. Abstracts, 97, 44, Abstract No. [16807g] (1982).

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