Process for the resolution of pyrano[3,4-b]indole-1-acetic acids

Details Process for the resolution of pyrano[3,4-b]indole-1-acetic acids Process for the resolution of pyrano[3,4-b]indole-1-acetic acids

1985-05-14

1986-08-05

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514411, 549385, C07D491052

Patent

active

046044698

ABSTRACT:
Mixtures of racemic (+)pyrano[3,4-b]indole-1-acetic acids are resolved with (-)-borneol to obtain the substantially pure (+) and (-)-enantiomers. The resolution involves the formation of a mixture of the diastereoisomeric pyrano[3,4-b]indole-1-acetic acid, (-)-borneol esters, separation of the diastereoisomeric esters, and hydrolysis of the latter esters.

REFERENCES:
patent: 4501899 (1985-02-01), Abraham et al.
patent: 4515961 (1985-05-01), Demerson et al.
patent: 4520203 (1985-05-01), Abraham et al.
Demerson et al., J. Med. Chem. 1983, 26, 1778-1780.

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