N-chloro-amino acid derivatives exhibiting antibacterial activit

Details N-chloro-amino acid derivatives exhibiting antibacterial activit N-chloro-amino acid derivatives exhibiting antibacterial activit

1976-03-08

1977-08-30

Turner, V. D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260482R, 424177, A01N 924

Patent

active

040455785

ABSTRACT:
There is provided, a novel class of compounds exhibiting antibacterial activity, said compounds having the formula: ##STR1## wherein X and Y each represent a member which may be the same or different selected from the group consisting of H and Cl with the proviso that X and Y cannot represent H simultaneously; R.sub.1 and R.sub.2 each represent a member which may be the same or different selected from the group consisting of an n- or branched alkyl group of from 1 to 20 carbon atoms, an aryl group (phenyl, naphthyl, etc.) ##STR2## WHEREIN N REPRESENTS AN INTEGER OF FROM 2 - 5; AND Z represents a member selected from the group consisting of an --OR.sub.3 group, ##STR3## WHEREIN R.sub.4 and R.sub.5 each represent a member which may be the same or different selected from the group consisting of H and an alkyl group of from 1 - 3 carbon atoms, wherein R.sub.6 and R.sub.7 each represent a member which may be the same or different selected from the group consisting of R.sub.1, R.sub.2, or H when X is not Cl or R.sub.1 and R.sub.2 when X is Cl, wherein R.sub.1 and R.sub.2 are as defined above, wherein X is as defined above, and wherein R.sub.3 in each case represents a member selected from the group consisting of an n- or branched alkyl group of from 2 - 20 carbon atoms, a --OCH.sub.2 CH.sub.2 --(OCH.sub.2 CH.sub.2).sub.n --OR.sub.1 group, wherein R.sub.1 is defined as above and n represents an integer of from 1 - 11, ##STR4## WHEREIN W represents a member selected from the group consisting of H, an- or branched alkyl group of from 1 - 20 carbon atoms, a halogen atom (Cl, Br, I), an --OR.sub.8 group, ##STR5## WHEREIN R.sub.4 and R.sub.5 are as defined above and R.sub.8 represents a member selected from the group consisting of H and R.sub.1, wherein R.sub.1 is as defined above, ##STR6## WHEREIN N REPRESENTS AN INTEGER OF FROM 1 - 20 AND R.sub.1 is as defined above,

REFERENCES:
patent: 3530162 (1970-09-01), Fuchs
patent: 3966796 (1976-06-01), Kaminski et al.

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