N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea com

Details N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea com N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea com

1992-02-26

1992-12-08

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514461, 514327, 514336, 546178, 546283, 549479, C07D40502, C07D30740, A61K 3147, A61K 3134, A61K 3144

Patent

active

051698544

ABSTRACT:
Compounds useful in inhibiting the biosynthesis of leukotrienes have the structure ##STR1## where M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group, R.sup.4 is alkyl, cycloalkyl or --NR.sup.5 R.sup.6, where R.sup.5 and R.sup.6 are hydrogen, alkyl, cycloalkyl or alkanoyl, where A is a valence bond or is a straight or branched divalent alkylene group of from one to twelve carbon atoms, R.sup.2 and R.sup.3 are independently selected from hydrogen, straight or branched alkyl of from one to twelve carbon atoms, halogen, or trifluoroalkyl, and R.sup.1 is selected from phenoxy, phenylthio, 2-, 3-, or 4-pyridyloxy, 1 or 2-naphthyloxy, or 2,4,5, or 8-quinolyloxy, all optionally substituted with alkyl, haloalkyl, alkoxy, hydroxy or halogen.

REFERENCES:
patent: 4097487 (1978-06-01), Murakami et al.
patent: 4738986 (1988-04-01), Kneen et al.
patent: 4769461 (1988-09-01), Musser et al.

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